Article
Serotyping HIV type 1 by antibody binding to the V3 loop: relationship to viral genotype. WHO Network for HIV Isolation and Characterization.
AIDS research and human retroviruses - 1 Nov 1994
Cheingsong-Popov R, Lister S, Callow D, Kaleebu P, Beddows S, Weber J
Abstract excerpt
We have investigated whether peptides representing the HIV-1 principal neutralization domain (V3) can be used as antigens in antibody-binding assays to predict the genotypes of the subjects' virus. Serum samples collected from HIV-1-infected subjects from the four WHO-sponsored vaccine evaluation sites (Uganda, Rwanda, Thailand, and Brazil) were characterized by antibody binding to a panel of synthetic V3...
Topics
- AIDS Vaccines
- Amino Acid Sequence
- Animals
- Antigenic Variation
- Brazil
- Cross Reactions
- Enzyme-Linked Immunosorbent Assay
- Genotype
- HIV Antibodies
- HIV Antigens
- HIV Envelope Protein gp120
