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Article

Automated Detection of Conformational Epitopes Using Phage Display Peptide Sequences

1 Jan 2009

Abstract excerpt

BACKGROUND: Precise determination of conformational epitopes of neutralizing antibodies represents a key step in the rational design of novel vaccines. A powerful experimental method to gain insights on the physical chemical nature of conformational epitopes is the selection of linear peptides that bind with high affinities to a monoclonal antibody of interest by phage display technology. However, the structural...

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Identifiers

PMID: 20140073
DOI: 10.4137/bbi.s2745

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