Sequence variation in the E7 gene of human papillomavirus type 18 in tumor and non-tumor patients and antibody response to a conserved seroreactive epitope.

doi:10.1002/ijc.2910530214

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Article

Sequence variation in the E7 gene of human papillomavirus type 18 in tumor and non-tumor patients and antibody response to a conserved seroreactive epitope.

International journal of cancer - 21 Jan 1993

ter Meulen J, Schweigler A C, Eberhardt H C, Luande J, Mgaya H N, Müller M, Bleul C, Ulken V, Ikenberg H, Pawlita M

Abstract excerpt

We have determined nucleotide sequences of the E7 open reading frame (ORF) of human papillomavirus type 18 (HPV-18) isolates obtained from 18 cervical carcinomas from Tanzanian and German patients and 8 cervical scrapings from Tanzanian non-tumor patients. The HPV-18 prototype sequence was detected in only 3 out of 26 isolates. Silent mutations were found at nt positions 640 and 751, whereas the mutations...

Topics

Antibodies, Viral
Base Sequence
Cell Line
DNA-Binding Proteins
Epitopes
Female
Germany
Humans
Molecular Sequence Data
Mutation
Oncogene Proteins, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open Reading Frames

Papillomaviridae

Polymerase Chain Reaction

Tanzania

Tumor Virus Infections

Uterine Cervical Neoplasms

Source

Open in PubMed

Identifiers

PMID: 7678831
DOI: 10.1002/ijc.2910530214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7678831-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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