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Article

Classification of mutations in the human CD40 ligand, gp39, that are associated with X-linked hyper IgM syndrome.

Protein science : a publication of the Protein Society - 1 Mar 1996

Bajorath J, Seyama K, Nonoyama S, Ochs H D, Aruffo A

Abstract excerpt

The interaction between the T cell activation antigen gp39 and CD40, its receptor CD40 on B cells, plays a critical role in the regulation of humoral immune responses. Using a detailed three-dimensional model of the gp39 extracellular region, we have analyzed 20 mutations in gp39 that were, with one exception, isolated from patients with X-linked hyper IgM (XHIM) syndrome. On the basis of this analysis, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16509032
DOI: 10.1002/pro.5560050316
PMCID: PMC2143372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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