Directional mutation pressure, mutator mutations, and dynamics of molecular evolution.

Abstract excerpt

Using a general form of the directional mutation theory, this paper analyzes the effect of mutations in mutator genes on the G+C content of DNA, the frequency of substitution mutations, and evolutionary changes (cumulative mutations) under various degrees of selective constraints. Directional mutation theory predicts that when the mutational bias between A/T and G/C nucleotide pairs is equilibrated with the base...

Topics

• Animals
• Base Composition
• Biological Evolution
• Codon
• DNA
• Genetics, Population
• Models, Genetic