Spatial working and reference memory in rats bred for autonomic sensitivity to cholinergic stimulation: acquisition, accuracy, speed, and effects of cholinergic drugs.

doi:10.1006/nlme.1995.1012

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Article

Spatial working and reference memory in rats bred for autonomic sensitivity to cholinergic stimulation: acquisition, accuracy, speed, and effects of cholinergic drugs.

Neurobiology of learning and memory - 1 Mar 1995

Bushnell P J, Levin E D, Overstreet D H

Abstract excerpt

Rat lines were selected by breeding for sensitivity to signs of autonomic stimulation (hypotherma, loss of body weight, and reduced water intake) induced by the cholinesterase inhibitor diisopropyl fluorophosphate (DFP). These lines have since been maintained for 10 generations by continued selection for hypothermic responsiveness to the muscarinic agonist oxotremorine. The sensitive rats (Flinders Sensitive...

Topics

Animals
Arousal
Autonomic Nervous System
Body Temperature Regulation
Body Weight
Cholinergic Agents
Conditioning, Operant
Discrimination Learning
Drinking
Genotype
Isoflurophate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Maze Learning

Mental Recall

Motivation

Orientation

Oxotremorine

Pattern Recognition, Visual

Source

Open in PubMed

Identifiers

PMID: 7663885
DOI: 10.1006/nlme.1995.1012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7663885-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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