Article
[The detection of the genotoxic and mutagenic activities of disperse azo dyes for their hygienic standardization].
Meditsina truda i promyshlennaia ekologiia - 1 Jan 1995
Palagina I A, Deveĭkis D N, Vashchuk N A, Kaliuzhnyĭ G L
Abstract excerpt
Evaluating level and synthesis of DNA in liver cells, counting occurrence of dominant lethal mutations, the authors studied molecular and genetic effects of dispersed polyaether mononitrodyes Orange 2K and Red-Brown G after the peroral administration and the chronic inhalation (2.5 and 4 months). Red-Brown G examined in acute and chronic exposures appeared to be powerful mutagen. Orange 2K induced minor changes...
Topics
- Air Pollutants, Occupational
- Animals
- Azo Compounds
- Coloring Agents
- DNA
- Dose-Response Relationship, Drug
- Genes, Dominant
- Genes, Recessive
- Liver
- Male
- Maximum Allowable Concentration