Article
Effects of MHC-encoded TAP1 and TAP2 gene polymorphism and matching on kidney graft rejection.
Transplantation - 15 Aug 1995
Chevrier D, Giral M, Braud V, Bourbigot B, Muller J Y, Bignon J D, Soulillou J P
Abstract excerpt
The products of TAP1 and TAP2 genes, recently mapped within the MHC class II region, are involved in antigen presentation by MHC class I molecules, especially in the transport of endogenous peptides. As for most MHC genes, a polymorphism has been described and the possibility that it could influence the recipient immune response by modulating antigen presentation in kidney transplantation has been tested. The aim...
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