Article
Role of major histocompatibility complex and ethnicity in acute renal graft rejection.
Transplantation proceedings - 1 Jan 2000
Torres-Machorro A, Camorlinga-Tagle N, Rodríguez-Ortiz C, Palafox D, González N, López M, Castelán N, de Leo C, Vilatobá M, Gabilondo B, Alberú Gómez J, Morales-Buenrostro L, Granados J
Abstract excerpt
BACKGROUND: The major histocompatibility complex (MHC) plays a main role in antigen presentation. Class I, II, and III genes form defined "blocks" of conserved DNA sequences (conserved extended haplotypes) that are useful to follow the ancestry of a population. Each variant encodes a specific peptide that determines a particular individual's immune response. In addition, differential expression of HLA antigens in...
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