Article
Abnormalities in esophageal smooth muscle induced by mutations in collagen XIX.
Histochemistry and cell biology - 1 Feb 2022
Sato Haruna, Jin Kyoko, Yano Shinji, Yasuda Aiko, Adachi Sawako, Yoshioka Hidekatsu, Kitamura Hirokazu, Sasaki Takako
Abstract excerpt
Collagen XIX is a nonfibrillar collagen that localizes in restricted tissues at very low amounts. A previous study on Col19a1 null mice revealed that collagen XIX is involved in esophageal muscle physiology and morphogenesis. Here, we use histological analysis to show that mice with a Col19a1 mutant lacking the NC3 domain and seven collagen triplets display abnormal transition of smooth to striated muscle in the...
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