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Article

A universal mechanism ties genotype to phenotype in trinucleotide diseases.

PLoS computational biology - 1 Nov 2007

Kaplan Shai, Itzkovitz Shalev, Shapiro Ehud

Abstract excerpt

Trinucleotide hereditary diseases such as Huntington disease and Friedreich ataxia are cureless diseases associated with inheriting an abnormally large number of DNA trinucleotide repeats in a gene. The genes associated with different diseases are unrelated and harbor a trinucleotide repeat in different functional regions; therefore, it is striking that many of these diseases have similar correlations between...

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Identifiers

PMID: 18039028
DOI: 10.1371/journal.pcbi.0030235
PMCID: PMC2082501

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