Article
Genetic polymorphism within HLA-A*02: significant allelic variation revealed in different populations.
Tissue antigens - 1 Apr 1995
Krausa P, Brywka M, Savage D, Hui K M, Bunce M, Ngai J L, Teo D L, Ong Y W, Barouch D, Allsop C E
Abstract excerpt
HLA-A2 is present at high frequency in most populations, as identified by serological and biochemical means. The value of these methods is limited by their failure to discriminate between the products of the 14 known allelic HLA-A*02 variants. The great majority of genetic polymorphism which defines the allelic variants is found in exons 2 and 3 of the A*02 genes. These exons encode the alpha-1 and alpha-2...
Topics
- Alleles
- Base Sequence
- Cell Line
- DNA
- Gene Frequency
- HLA-A Antigens
- HLA-A2 Antigen
- Humans
- Molecular Sequence Data
- Polymorphism, Genetic
- Racial Groups