Article
Molecular basis and expression of the LWa/LWb blood group polymorphism.
Blood - 15 Aug 1995
Hermand P, Gane P, Mattei M G, Sistonen P, Cartron J P, Bailly P
Abstract excerpt
The Landsteiner-Wiener (LW) blood group antigens reside on a 42-kD erythrocyte membrane glycoprotein that has recently been cloned. Here, we found that the molecular basis for the LWa/LWb polymorphism is determined by a single base pair mutation (A308G) that correlates with a Pvu II restriction site and results in a Gln70Arg amino acid substitution. COS-7 cells transfected with LWa or LWb cDNAs reacted with human...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Blood Group Antigens
- Cell Adhesion Molecules
- Chromosome Mapping
- Chromosomes, Human, Pair 19
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Humans