Article
Induction of chromosome loss in Saccharomyces cerevisiae strain D61.M by selected benzimidazole compounds.
Mutation research - 1 Jul 1995
Goin C J, Mayer V W
Abstract excerpt
Twenty-two benzimidazole compounds were tested for induction of chromosome loss (CHRL) in the diploid yeast Saccharomyces cerevisiae strain D61.M. Six compounds tested positive for CHRL induction: mebendazole, albendazole, RS-9237-000, fenbendazole, 2-benzimidazolylacetonitrile, and thiabendazole. Mebendazole, albendazole, RS-9237-000, and fenbendazole were strongly positive only after modified testing media were...
Topics
- Benzimidazoles
- Chromosome Deletion
- Chromosomes, Fungal
- Dose-Response Relationship, Drug
- Molecular Structure
- Phenotype
- Saccharomyces cerevisiae
- Structure-Activity Relationship