Article
Functional expression of sodium channel mutations identified in families with periodic paralysis.
Neuron - 1 Feb 1993
Cannon S C, Strittmatter S M
Abstract excerpt
Two mutations in the sodium channel alpha subunit that have been implicated as the cause of periodic paralysis were studied by functional expression in a mammalian cell line. Both mutations disrupted inactivation without affecting the time course of the onset of the sodium current or the single-c...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Electric Conductivity
- Electrophysiology
- Embryo, Mammalian
- Gene Expression
- Humans
- Kidney
- Kinetics
- Molecular Sequence Data
- Muscles
- Mutation
- Paralyses, Familial Periodic
- Polymerase Chain Reaction
- Rats
- Sodium Channels