Article
Estimation of the absolute bioavailability of flecainide using stable isotope technique.
European journal of clinical pharmacology - 1 Jan 1995
Hage K, Bühl K, Fischer C, Knebel N G
Abstract excerpt
Data on the absolute bioavailability of flecainide are controversial. We have investigated whether differences in metabolic clearances and/or the absorption profile might be responsible for the variability in its absolute bioavailability. Six subjects with a wide range of flecainide metabolic clearances (85-407 ml.min-1) simultaneously received the drug by the IV and oral routes; the oral dose was labelled with...
Topics
- Administration, Oral
- Adult
- Biological Availability
- Female
- Flecainide
- Humans
- Injections, Intravenous
- Male
- Phenotype
- Polymorphism, Genetic
- Radioisotope Dilution Technique