Article
[Expression of sdi1, a potent inhibitor of cdk2 kinase, cdk2 and G1 cyclins and mutation of sdi1 in human gastric carcinomas].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jun 1995
Akama Y, Yasui W, Kuniyasu H, Yokozaki H, Tahara H, Noda A, Tahara E
Abstract excerpt
Sdi1, also known as Cip1/Waf1, is a potent inhibitor of G1 cyclin-dependent kinases, which is induced by wild type p53 but not by mutant p53. Expression of mRNAs for sdil, cdk2 and G1 cyclins was examined in gastric carcinomas. All the cell lines expressing very low or undetectable level of sdil...
Topics
- CDC2-CDC28 Kinases
- Cell Cycle Proteins
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor Proteins
- Cyclin-Dependent Kinases
- Dual-Specificity Phosphatases
- Gene Expression
- Genes, p53
- Humans
- Mutation
- Phosphoprotein Phosphatases
- Protein Serine-Threonine Kinases
- Protein Tyrosine Phosphatases
- RNA, Messenger
- Stomach Neoplasms