Positive R plasmid mutator effect on chromosomal mutation to nalidixic acid resistance in nalidixic acid-exposed cultures of Escherichia coli.

Abstract excerpt

Mutation frequencies to nalidixic acid resistance (15 mg/L in nutrient agar) were determined for derivatives of Escherichia coli AB1157 carrying the mutator plasmids R46, R391 or pYD1, or the non-mutator plasmid RP4. Frequencies of mutation remained constant in cultures of AB1157(R46) growing exponentially in drug-free broth, at a level about 12-fold higher than in the strain without plasmid. Mutation frequencies...

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