Article
Genetic polymorphisms and susceptibility to cancer development.
Pharmacogenetics - 1 Jan 1995
Sugimura T, Inoue R, Ohgaki H, Ushijima T, Canzian F, Nagao M
Abstract excerpt
Humans show heterogeneous susceptibility to cancer development, suggesting the involvement of various genetic backgrounds in control of the production of endogenous carcinogens, the metabolism of carcinogens, the repair of DNA damage, cell proliferation and defence mechanisms including immune rea...
Topics
- Animals
- BRCA1 Protein
- Breast Neoplasms
- Female
- Gastric Mucosa
- Genetic Predisposition to Disease
- Humans
- Japan
- Lod Score
- Methylnitronitrosoguanidine
- Middle Aged
- Neoplasm Proteins
- Neoplasms
- Ovarian Neoplasms
- Polymorphism, Genetic
- Rats
- Rats, Inbred ACI
- Rats, Inbred BUF