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Article

Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 1996

Magyar J P, Martini R, Ruelicke T, Aguzzi A, Adlkofer K, Dembic Z, Zielasek J, Toyka K V, Suter U

Abstract excerpt

An intrachromosomal duplication containing the PMP22 gene is associated with the human hereditary peripheral neuropathy Charcot-Marie-Tooth disease type 1A, and PMP22 overexpression as a consequence of increased PMP22 gene dosage has been suggested as causative event in this frequent disorder of peripheral nerves. We have generated transgenic mice that carry additional copies of the pmp22 gene to prove that...

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Source

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Identifiers

PMID: 8757248
PMCID: PMC6578876

Genes

PMP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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