Article
Comparable Effects of the Androgen Derivatives Danazol, Oxymetholone and Nandrolone on Telomerase Activity in Human Primary Hematopoietic Cells from Patients with Dyskeratosis Congenita.
International journal of molecular sciences - 29 Sept 2020
Vieri Margherita, Kirschner Martin, Tometten Mareike, Abels Anne, Rolles Benjamin, Isfort Susanne, Panse Jens, Brümmendorf Tim H, Beier Fabian
Abstract excerpt
Dyskeratosis congenita (DKC) is a rare inherited disease of impaired telomere maintenance that progressively leads to multi-organ failure, including the bone marrow. By enhancing telomerase activity, androgen derivatives (ADs) are a potential therapeutic option able to re-elongate previously shortened telomeres. Danazol, oxymetholone, and nandrolone are ADs most frequently used to treat DKC. However, no direct in...
Topics
- Androgens
- Cell Cycle Proteins
- Danazol
- Dyskeratosis Congenita
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
- Humans
- Mutation
- Nandrolone