Article
Mutational analysis of human papillomavirus type 16 E6 protein: transforming function for human cells and degradation of p53 in vitro.
Virology - 1 Oct 1995
Nakagawa S, Watanabe S, Yoshikawa H, Taketani Y, Yoshiike K, Kanda T
Abstract excerpt
The E6 oncoprotein of human papillomavirus type 16 (HPV 16) [151amino acids (AA) long] contains four metal-binding motifs, C-X-X-C, and is postulated to form two 29-AA finger-like structures in the N-terminal and C-terminal halves, which mediate degradation of p53 and binding to p53, respectively...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cell Nucleus
- Cell Transformation, Viral
- Chlorocebus aethiops
- Cytoplasm
- Humans
- Kidney
- Molecular Sequence Data
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Papillomavirus E7 Proteins
- Repressor Proteins
- Tumor Suppressor Protein p53
- Zinc Fingers