Article
Lipopolysaccharides of polymyxin B-resistant mutants of Escherichia coli are extensively substituted by 2-aminoethyl pyrophosphate and contain aminoarabinose in lipid A.
Molecular microbiology - 1 Apr 1995
Nummila K, Kilpeläinen I, Zähringer U, Vaara M, Helander I M
Abstract excerpt
Lipopolysaccharides (LPS) of two polymyxin-resistant (pmr) mutants and the corresponding parent strain of Escherichia coli were chemically analysed for composition and subjected to 31P-NMR (nuclear magnetic resonance) for assessment of phosphate substitution. Whereas the saccharide portions, fatty acids, and phosphate contents were similar in wild-type and pmr LPS, the latter contained two- to threefold higher...
Topics
- Amino Sugars
- Arabinose
- Diphosphates
- Drug Resistance, Microbial
- Escherichia coli
- Ethanolamine
- Ethanolamines
- Lipid A
- Lipopolysaccharides
- Magnetic Resonance Spectroscopy