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Article

Proline in a transmembrane helix compensates for cavities in the photosynthetic reaction center.

Journal of molecular biology - 29 Sept 1995

Schiffer M, Ainsworth C F, Deng Y L, Johnson G, Pascoe F H, Hanson D K

Abstract excerpt

A site-specific double mutant, in which the large aromatic residues M208Tyr and L181Phe in the interior of the photosynthetic reaction center (RC) complex were replaced by smaller threonine residues, showed a dramatic reduction in the number of assembled complexes and was incapable of photosynthetic growth. The cavity created by the smaller side-chains was thought to interfere with the stability and/or assembly...

Topics

Cell Membrane
Hot Temperature
Mutagenesis, Site-Directed
Phenotype
Photosynthetic Reaction Center Complex Proteins
Proline
Protein Denaturation
Protein Folding
Protein Structure, Secondary
Rhodobacter capsulatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Suppression, Genetic

Source

Identifiers

PMID: 7563066
DOI: 10.1006/jmbi.1995.0512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7563066-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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