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Article

The influence of exo-enzyme S and proteases on endogenous Pseudomonas aeruginosa bacteraemia in mice.

Journal of medical microbiology - 1 Oct 1995

Hirakata Y, Furuya N, Tateda K, Matsumoto T, Yamaguchi K

Abstract excerpt

The role of Pseudomonas aeruginosa exo-enzymes was evaluated in a murine model of endogenous bacteraemia in which the bacteria invaded the bloodstream after oral dosing. Although an elastase mutant PAO-E64 was as virulent as its parent strain PAO1, an exo-enzyme S-deficient mutant, DG1-ExS5 and alkaline protease mutants PAKS-16, PAKS-17, PAKS-19, were less virulent than their parent strains, DG1 and PAKS-1,...

Topics

Animals
Bacteremia
Bacterial Proteins
Disease Models, Animal
Endopeptidases
Male
Metalloendopeptidases
Mice
Mutation
Poly(ADP-ribose) Polymerases
Pseudomonas Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pseudomonas aeruginosa

Specific Pathogen-Free Organisms

Virulence

Source

Identifiers

PMID: 7562986
DOI: 10.1099/00222615-43-4-258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7562986-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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