Article
Marrow-derived heparan sulfate proteoglycan mediates the adhesion of hematopoietic progenitor cells to cytokines.
Experimental hematology - 1 Oct 1995
Bruno E, Luikart S D, Long M W, Hoffman R
Abstract excerpt
Heparan sulfate proteoglycan (HS-PG), an important component of the human bone marrow extracellular matrix (ECM), is believed to influence hematopoietic progenitor cell development by binding and localizing growth factors to specific niches within the hematopoietic microenvironment. We utilized a...
Topics
- Bone Marrow
- Bone Marrow Cells
- Cell Adhesion
- Cells, Cultured
- Cytokines
- Erythropoietin
- Extracellular Matrix
- Granulocyte-Macrophage Colony-Stimulating Factor
- Growth Substances
- Hematopoietic Stem Cells
- Heparan Sulfate Proteoglycans
- Heparitin Sulfate
- Humans
- Interleukin-3
- Phenotype
- Proteoglycans
- Recombinant Fusion Proteins
- Recombinant Proteins