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Article

Presence of Endogenous Nicks in DNA of Ejaculated Human Spermatozoa and its Relationship to Chromomycin A3 Accessibility1

1 Apr 1995

Abstract excerpt

During spermiogenesis, mammalian chromatin undergoes replacement of nuclear histones by protamines, resulting in a DNA that is highly condensed in the mature sperm. We have previously demonstrated that a percentage of human spermatozoa exhibit 1) positivity to the guanine-cylosine-specific chromomycin A3 (CMA3) fluorochrome and 2) the presence of endogenous nicks in their DNA. In situ protamination of mature...

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PMID: 7540051
DOI: 10.1095/biolreprod52.4.864

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