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Article

Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase.

Biochemistry - 30 May 1995

Sarafianos S G, Pandey V N, Kaushik N, Modak M J

Abstract excerpt

In order to define the role of Gln151 in the polymerase function of HIV-1 RT, we carried out site-directed mutagenesis of this residue by substituting it with a conserved (Q151N) and a nonconserved residue (Q151A). Q151N exhibited properties analogous to those of the wild-type enzyme, while Q151A has severely impaired polymerase activity. The Q151A mutant exhibited a 15-100-fold reduction in kcat with RNA...

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Identifiers

PMID: 7539293
DOI: 10.1021/bi00021a036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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