Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase.

doi:10.1021/bi00021a036

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Article

Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase.

Biochemistry - 30 May 1995

Sarafianos S G, Pandey V N, Kaushik N, Modak M J

Abstract excerpt

In order to define the role of Gln151 in the polymerase function of HIV-1 RT, we carried out site-directed mutagenesis of this residue by substituting it with a conserved (Q151N) and a nonconserved residue (Q151A). Q151N exhibited properties analogous to those of the wild-type enzyme, while Q151A...

Topics

Amino Acid Sequence
Base Sequence
Cations, Divalent
Cloning, Molecular
Deoxyribonucleotides
Glutamine
HIV Reverse Transcriptase
HIV-1
Hydrogen-Ion Concentration
Molecular Sequence Data
Mutation
Nucleotidyltransferases
RNA-Directed DNA Polymerase
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 7539293
DOI: 10.1021/bi00021a036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7539293-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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