Article
Amino-acid residues involved in biological functions of the cytolytic enterotoxin from Aeromonas hydrophila.
Gene - 14 Apr 1995
Ferguson M R, Xu X J, Houston C W, Peterson J W, Chopra A K
Abstract excerpt
Some amino acid (aa) residues within the cytolytic enterotoxin (Act) of Aeromonas hydrophila essential for biological activity were identified. Act is a 52-kDa polypeptide, possessing hemolytic, cytotoxic and enterotoxic activities. By deletion analysis, generation of anti-peptide Ab, and site-directed mutagenesis we showed that two regions in Act (aa 245-274 and 361-405) were very important for biological...
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