Article
Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase.
Antimicrobial agents and chemotherapy - 1 Sept 1994
Boyer P L, Ding J, Arnold E, Hughes S H
Abstract excerpt
We constructed plasmid vectors that simultaneously express both the p66 and p51 subunits of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) in Escherichia coli. These vectors allow us to generate HIV-1 RT heterodimers in which either the p66 or the p51 subunit has the wild-...
Topics
- Antiviral Agents
- Benzodiazepines
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- Imidazoles
- Macromolecular Substances
- Mutation
- Plasmids
- Protein Conformation
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors
- Spiro Compounds
- Substrate Specificity
- Thymidine