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Article

Biochemical mechanism of HIV-1 resistance to rilpivirine.

The Journal of biological chemistry - 2 Nov 2012

Singh Kamalendra, Marchand Bruno, Rai Devendra K, Sharma Bechan, Michailidis Eleftherios, Ryan Emily M, Matzek Kayla B, Leslie Maxwell D, Hagedorn Ariel N, Li Zhe, Norden Pieter R, Hachiya Atsuko, Parniak Michael A, Xu Hong-Tao, Wainberg Mark A, Sarafianos Stefan G

Abstract excerpt

Rilpivirine (RPV) is a second generation nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) that efficiently inhibits HIV-1 resistant to first generation NNRTIs. Virological failure during therapy with RPV and emtricitabine is associated with the appearance of E138K and M184I mutations in RT. Here we investigate the biochemical mechanism of RT inhibition and resistance to RPV. We used two transient...

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Identifiers

PMID: 22955279
DOI: 10.1074/jbc.M112.398180
PMCID: PMC3488081

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Source receipt: pubmed, retrieved 7 Sept 2026.

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