Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant.

doi:10.1111/1523-1747.ep12613462

Back to search

Article

Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant.

The Journal of investigative dermatology - 1 Jan 1995

Amagai M, Fujimori T, Masunaga T, Shimizu H, Nishikawa T, Shimizu N, Takeichi M, Hashimoto T

Abstract excerpt

We examined whether classic cadherins play a role in the formation of desmosomes using a mouse keratinocyte, PAMcN390 delta cell, which shows disrupted classic-cadherin-mediated cell adhesion by introduction of a dominant-negative mutant of N-cadherin. The expression of the mutant did not alter t...

Topics

Animals
Cadherins
Calcium
Cell Adhesion
Cell Line
Cytoskeletal Proteins
Desmoplakins
Desmosomes
Keratinocytes
Keratins
Mice
Mutation
Solubility

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.