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Article

Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: implications for the mechanism of polymerase action.

Protein engineering - 1 Dec 1997

Kroeger Smith M B, Michejda C J, Hughes S H, Boyer P L, Janssen P A, Andries K, Buckheit R W, Smith R H

Abstract excerpt

A computer model of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) either alone, or complexed with a non-nucleoside inhibitor (NNI), was constructed using crystal coordinate data from a subset of the protein surrounding the binding pocket region. Molecular mechanics calculations were carried out on solvated wild-type RT and RT that contained modifications corresponding to...

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PMID: 9542999
DOI: 10.1093/protein/10.12.1379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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