Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 RT nonnucleoside inhibitors and their interaction with RT for antiviral drug development.

Infectious disorders drug targets - 1 Dec 2006

Zhou Zhigang, Lin Xin, Madura Jeffry D

Abstract excerpt

Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent component of highly active antiretroviral therapy (HAART) in the treatment of human immunodeficiency virus type 1 (HIV-1) infections. One of the most serious problems associated with NNRTIs is that the virus exhibits resistance to the drug through mutation once the virus is exposed to the drug. New inhibitors effective against...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Design
Share to Drug Resistance, Viral
Share to HIV-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Reverse Transcriptase

Share to Molecular Structure

Share to Quantitative Structure-Activity Relationship

Share to Reverse Transcriptase Inhibitors

Source

Identifiers

PMID: 17168804
DOI: 10.2174/187152606779025833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 RT nonnucleoside inhibitors and their interaction with RT for antiviral drug development.PMID 17168804Read ↗

The Current Status of the NNRTI Family of Antiretrovirals Used Against HIV InfectionSemantic proximity Read ↗

Looking for an Active Conformation of the Future HIV Type-1 Non-Nucleoside Reverse Transcriptase InhibitorsSemantic proximity Read ↗

Structure-enhanced methods in the development of non-nucleoside inhibitors targeting HIV reverse transcriptase variants.Semantic proximity Read ↗

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse TranscriptaseSemantic proximity Read ↗

Design Strategies of Novel NNRTIs to Overcome Drug ResistanceSemantic proximity Read ↗

Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitorsSemantic proximity Read ↗

HIV-1 Reverse Transcriptase: A Therapeutical Target in the SpotlightSemantic proximity Read ↗

Molecular and structural aspects of clinically relevant mutations related to the approved non-nucleoside inhibitors of HIV-1 reverse transcriptase.Semantic proximity Read ↗

Molecular insights into the mechanisms of HIV-1 reverse transcriptase resistance to nucleoside analogs.Semantic proximity Read ↗

Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance.Semantic proximity Read ↗

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.Semantic proximity Read ↗

Molecular Docking Studies of HIV-1 Resistance to Reverse Transcriptase Inhibitors: Mini-Review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.