Article
RNA editing: transfer of genetic information from gRNA to precursor mRNA in vitro.
Science (New York, N.Y.) - 7 Oct 1994
Seiwert S D, Stuart K
Abstract excerpt
RNA editing in the mitochondrion of Trypanosoma brucei extensively alters the adenosine triphosphate synthase (ATPase) subunit 6 precursor messenger RNA (pre-mRNA) by addition of 447 uridines and removal of 28 uridines. In vivo, the guide RNA gA6[14] is thought to specify the deletion of two uridines from the editing site closest to the 3' end. In this study, an in vitro system was developed that accurately...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Animals
- Base Composition
- Base Sequence
- Mitochondria
- Molecular Sequence Data
- Mutation
- RNA
- RNA Editing
- RNA Precursors
- RNA, Guide, Kinetoplastida