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Article

RNA editing: transfer of genetic information from gRNA to precursor mRNA in vitro.

Science (New York, N.Y.) - 7 Oct 1994

Seiwert S D, Stuart K

Abstract excerpt

RNA editing in the mitochondrion of Trypanosoma brucei extensively alters the adenosine triphosphate synthase (ATPase) subunit 6 precursor messenger RNA (pre-mRNA) by addition of 447 uridines and removal of 28 uridines. In vivo, the guide RNA gA6[14] is thought to specify the deletion of two uridines from the editing site closest to the 3' end. In this study, an in vitro system was developed that accurately...

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Identifiers

PMID: 7524149
DOI: 10.1126/science.7524149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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RNA editing: transfer of genetic information from gRNA to precursor mRNA in vitro.PMID 7524149Read ↗

Alternative mRNA editing in trypanosomes is extensive and may contribute to mitochondrial protein diversity.Semantic proximity Read ↗

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RNA editing in trypanosomesSemantic proximity Read ↗

Disruption of a gene encoding a novel mitochondrial DEAD-box protein in Trypanosoma brucei affects edited mRNAs.Semantic proximity Read ↗

Trypanosome RNA editing: the complexity of getting U in and taking U outSemantic proximity Read ↗

Trypanosoma brucei RNA Editing: Coupled Cycles of U Deletion Reveal Processive Activity of the Editing ComplexSemantic proximity Read ↗

Cell-line specific RNA editing patterns in Trypanosoma brucei suggest a unique mechanism to generate protein variation in a system intolerant to genetic mutations.Semantic proximity Read ↗

Mitochondrial dual-coding genes in Trypanosoma brucei.Semantic proximity Read ↗

KREPA6 functions in RNA editing catalytic complex structural organization and gRNA utilization in Trypanosoma brucei.Semantic proximity Read ↗

Trypanosome RNA Editing Mediator Complex proteins have distinct functions in gRNA utilizationSemantic proximity Read ↗

RNA editing in kinetoplastid protozoaSemantic proximity Read ↗

A mRNA determinant of gRNA-directed kinetoplastid editing.Semantic proximity Read ↗

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