Article
A mRNA determinant of gRNA-directed kinetoplastid editing.
Nucleic acids research - 15 Jun 2001
Kabb A L, Oppegard L M, McKenzie B A, Connell G J
Abstract excerpt
Several mitochondrial mRNAs of the kinetoplastid protozoa do not encode a functional open reading frame until they have been edited through the addition or deletion of U nucleotides at specific sites. Genetic information specifying the location and extent of editing is present on guide RNAs (gRNAs). The sequence adjacent to most mRNA editing sites has a high purine content which previously has been proposed to...
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