Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins.

The Journal of biological chemistry - 14 Oct 1994

Ward C L, Kopito R R

Abstract excerpt

Mutant (delta F508) and wild-type cystic fibrosis transmembrane conductance regulator (CFTR) were synthesized initially as an approximately 140-kDa core-glycosylated precursor, which, in the case of wild-type CFTR, was chased to an approximately 160 kDa form bearing complex oligosaccharides. Mutant CFTR disappeared from the detergent-soluble cell extract with rapid (t1/2 = 27 min) kinetics. Only approximately 25%...

Topics

Amino Acid Sequence
Brefeldin A
Carcinoma
Cell Compartmentation
Colonic Neoplasms
Cyclopentanes
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Endoplasmic Reticulum
Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Membrane Proteins

Molecular Sequence Data

Mutation

Protein Biosynthesis

Protein Folding

Protein Precursors

Protein Processing, Post-Translational

Source

Identifiers

PMID: 7523390

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7523390-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins.PMID 7523390Read ↗

C-terminal Truncations Destabilize the Cystic Fibrosis Transmembrane Conductance Regulator without Impairing Its BiogenesisSemantic proximity Read ↗

Endocytic Trafficking Routes of Wild Type and ΔF508 Cystic Fibrosis Transmembrane Conductance RegulatorSemantic proximity Read ↗

Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.Semantic proximity Read ↗

Cystic fibrosis mutations lead to carboxyl-terminal fragments that highlight an early biogenesis step of the cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

The Delta F508 mutation shortens the biochemical half-life of plasma membrane CFTR in polarized epithelial cells.Semantic proximity Read ↗

The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.Semantic proximity Read ↗

A mutation in the cystic fibrosis transmembrane conductance regulator generates a novel internalization sequence and enhances endocytic rates.Semantic proximity Read ↗

CFTR and chaperones: processing and degradation.Semantic proximity Read ↗

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.Semantic proximity Read ↗

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.Semantic proximity Read ↗

Non-conventional trafficking of the cystic fibrosis transmembrane conductance regulator through the early secretory pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.