Article
Administration of an anti-CD5 immunoconjugate to patients with rheumatoid arthritis: effect on peripheral blood mononuclear cells and in vitro immune function.
The Journal of rheumatology - 1 Apr 1994
Fishwild D M, Strand V
Abstract excerpt
OBJECTIVE: An immunoconjugate, CD5 Plus, composed of ricin A chain and murine IgG1 anti-CD5 monoclonal antibody is under investigation for treatment of rheumatoid arthritis. To understand better the mechanism of action of this agent, alterations in immune function and lymphocyte subpopulations we...
Topics
- Adult
- Antibodies, Monoclonal
- Antigens, CD
- Arthritis, Rheumatoid
- B-Lymphocyte Subsets
- CD5 Antigens
- Cytotoxicity, Immunologic
- Female
- Humans
- Immunoglobulin G
- Immunotoxins
- In Vitro Techniques
- Leukocyte Count
- Male
- Middle Aged
- Phenotype
- Receptors, IgG
- Ricin