Article
The polymorphism of the plasma inter-alpha-trypsin inhibitor (ITI) and its relationship to the heavy chain H1 subunit gene (ITIH1) at 3p211-212.
Human genetics - 1 Jul 1994
Vogt U, Sesboüé R, Bourguignon J, Diarra-Mehrpour M, Martin J P, Cleve H
Abstract excerpt
We investigated the ITI protein polymorphism in linkage analysis, using DraI and SstI as restriction fragment length polymorphism (RFLP) markers for the ITIH1 gene. Isoelectric focusing (IEF) classification from 76 individual plasma samples and RFLP analysis from the corresponding DNA preparations disclosed linkage disequilibrium between the phenotypic IEF patterns of the two common ITI alleles, ITI*1 and ITI*2,...
Topics
- Alleles
- Alpha-Globulins
- Chromosomes, Human, Pair 3
- Female
- Genetic Linkage
- Humans
- Male
- Pedigree
- Phenotype
- Polymorphism, Restriction Fragment Length
- Trypsin Inhibitors