[Possibilities of using Salmonella cya, crp mutants as vectors of an oral recombinant vaccine].

Abstract excerpt

The Salmonella typhimurium B-2/1 double mutant with cya and crp mutations was obtained by a recombination process. The mutant exhibited a low virulence and inability to utilize citrate. In terms of these properties, the mutant differs from the wild-type strain. The mutant is able to persist in the body of mice, cattle, and monkeys, provoking the immune response to its oral administration.

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