Article
Expression, purification and characterization of allelic variants of MSP-1(42) from Indian Plasmodium falciparum isolates.
Vaccine - 23 Jun 2010
Lalitha P V, Biswas S, Pillai C R, Seth R K, Saxena R K
Abstract excerpt
The C-terminal 19 and 42 kDa fragments of Plasmodium falciparum merozoite surface protein 1 (MSP-1) have shown to be protective in animals against lethal parasite challenge. The MSP-1(19) being highly conserved may lack sufficient number of T-cell epitopes in order to elicit a broader response in genetically diverse populations. The inclusion of additional epitopes from the N-terminal MSP-1(42) has shown to...
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