Mode of action of the cyclic depsipeptide antibiotic LL-AO341 beta 1 and partial characterization of a Staphylococcus aureus mutant resistant to the antibiotic.

doi:10.1093/jac/32.6.817

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Article

Mode of action of the cyclic depsipeptide antibiotic LL-AO341 beta 1 and partial characterization of a Staphylococcus aureus mutant resistant to the antibiotic.

The Journal of antimicrobial chemotherapy - 1 Dec 1993

Oliva B, Maiese W M, Greenstein M, Borders D B, Chopra I

Abstract excerpt

The antibacterial activity of the cyclic antibiotic LL-AO341 beta 1 was examined. The antibiotic was a narrow spectrum agent, effective principally against Gram-positive organisms. The intrinsic insusceptibility of Escherichia coli was due to exclusion of the drug by the outer membrane. The antibiotic was bactericidal against Staphylococcus aureus, and cell death was associated with lysis of the bacteria. The...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Cell Membrane
DNA, Bacterial
Drug Resistance, Microbial
Escherichia coli
Lipids
Microbial Sensitivity Tests
Mutation
Peptides

Peptidoglycan

Polymyxin B

RNA, Bacterial

Staphylococcus aureus

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