Article
Linkage disequilibrium between cystic fibrosis mutations and polymorphic 4-bp repeat within CFTR gene.
Biochemical medicine and metabolic biology - 1 Oct 1993
Gaitskhoki V S, Voronina O V, Potapova OYu, Kirjukhina L V, Gembitskaya T E, Kapranov N I, Petrova N V, Khafizova Z A, Schwartz E I
Abstract excerpt
The PCR technique was used in a study of the linkage of cystic fibrosis mutations and a polymorphic (GATT)n repeat in intron 6 of the CFTR gene. Absolute linkage disequilibrium was found between the common delta F-508 mutation and the (GATT)6 allele. This allele was also in linkage disequilibrium...
Topics
- Alleles
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA
- Gene Frequency
- Humans
- Linkage Disequilibrium
- Membrane Proteins
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid
- Russia