Article
Sequence variation within neutralizing epitopes of the envelope glycoprotein B of human cytomegalovirus: comparison of isolates from renal transplant recipients and AIDS patients.
The Journal of general virology - 1 Nov 1993
Roy D M, Grundy J E, Emery V C
Abstract excerpt
The envelope glycoprotein B of human cytomegalovirus (CMV) is a major target of the neutralizing antibody response against this virus, and hence has importance as a potential subunit vaccine. PCR was utilized to amplify DNA encoding the dominant antigenic determinant on this molecule, AD-1 (codons 552 to 635), and DNA sequencing was carried out in order to compare nucleotide variation in AD-1 between clinical...
Topics
- AIDS-Related Opportunistic Infections
- Amino Acid Sequence
- Base Sequence
- Cytomegalovirus
- DNA, Viral
- Epitopes
- Genetic Variation
- Humans
- Kidney Transplantation
- Molecular Sequence Data