Perturbed pKA-values in the denatured states of proteins.

doi:10.1006/jmbi.1995.0670

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Article

Perturbed pKA-values in the denatured states of proteins.

Journal of molecular biology - 15 Dec 1995

Tan Y J, Oliveberg M, Davis B, Fersht A R

Abstract excerpt

We show in this study that the ionisation equilibria of denatured proteins in pure water are inconsistent with the "fully-unfolded" conformation being an extended coil where the residues are isolated from one another by the intervening solvent. The effects of acid and salt on the stability of the...

Topics

Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Mutation
Peptides
Plant Proteins
Protein Denaturation
Protein Folding
Temperature

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