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Article

Human IL-17: a novel cytokine derived from T cells

1 Dec 1995

Abstract excerpt

A cDNA encoding human IL-17 (hIL-17) was cloned from a CD4+ T cell library. The predicted 155-amino acids sequence contains an N-terminal signal peptide and exhibits 72% amino acid identity with HVS13, an open reading frame from a T-lymphotropic Herpesvirus saimiri, and 63% with murine CTLA8. High levels of hIL-17 were induced from primary peripheral blood CD4+ T cells upon stimulation. When expressed in CV1/EBNA...

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PMID: 7499828
DOI: 10.4049/jimmunol.155.12.5483

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