Article
Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2004
Murphy Leigh, Cherlet Tracy, Adeyinka Adewale, Niu Yulian, Snell Linda, Watson Peter
Abstract excerpt
PURPOSE: To determine whether estrogen receptor (ER)-alpha specifically phosphorylated at Ser(118) is detectable in multiple human breast cancer biopsy samples. To gain insight into possible roles for P-Ser(118)-ERalpha in human breast cancer in vivo. EXPERIMENTAL DESIGN: A specific antibody for P-Ser(118)-ERalpha was validated for immunohistochemistry (IHC), and Western blot analysis confirmed IHC results. IHC...
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