Antiviral activity of phosphonoformate on rotavirus transcription and replication.

doi:10.1016/0166-3542(94)00085-m

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Article

Antiviral activity of phosphonoformate on rotavirus transcription and replication.

Antiviral research - 1 May 1995

Ríos M, Muñoz M, Spencer E

Abstract excerpt

The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of the Reoviridae, was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme pyrophosphate binding site. Replication of rotavirus in MA104 cells using differ...

Topics

Animals
Antiviral Agents
Cell Line
Foscarnet
Haplorhini
Mutation
RNA, Messenger
RNA, Viral
Rotavirus
Temperature
Transcription, Genetic
Virus Replication

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