Association and linkage studies of the TAQI A1 allele at the dopamine D2 receptor gene in samples of female and male alcoholics.

Abstract excerpt

To address the controversy surrounding DRD2 and alcoholism, we performed linkage and association studies utilizing alcoholic men from high-density families largely uncontaminated by other psychopathology and female alcoholics for whom secondary drug dependence (averaging 10 years later onset) was a prominent feature. The males and females were combined for a total of 52 alcoholics, and compared to 30 controls...

Topics

• Alcoholism
• Alleles
• Female
• Genetic Linkage
• Humans
• Male
• Polymorphism, Restriction Fragment Length
• Receptors, Dopamine D2