Article
Evidence for an association between nonsyndromic cleft lip with or without cleft palate and a gene located on the long arm of chromosome 4.
American journal of human genetics - 1 Nov 1995
Mitchell L E, Healey S C, Chenevix-Trench G
Abstract excerpt
Recent studies suggest that the familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL +/- P) is likely to be attributable to the effects of several susceptibility loci, acting in a multiplicative fashion. Two potential CL +/- P susceptibility loci (CSL), transforming growth factor alpha (TGFA) and retinoic acid receptor (RARA), have been identified through association studies. In...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- Cleft Lip
- Cleft Palate
- Genetic Linkage
- Humans
- Lod Score